General Pharmacology

Beta-blockers space drugs that tie to beta-adrenoceptors and also thereby block the binding of norepinephrine and also epinephrine to this receptors. This inhibits common sympathetic results that act v these receptors. Therefore, beta-blockers are sympatholytic drugs. Part beta-blockers, as soon as they tie to the beta-adrenoceptor, partially activate the receptor while preventing norepinephrine from binding to the receptor. This partial agonists therefore provide some "background" that sympathetic task while avoiding normal and magnified sympathetic activity. These certain beta-blockers (partial agonists) are said to own intrinsic sympathomimetic activity (ISA). Part beta-blockers also possess what is described as membrane stabilizing activity (MSA). This result is similar to the membrane stabilizing task of sodium-channels blockers that represent course I antiarrhythmics.

You are watching: Beta-adrenergic blocking agents decrease the oxygen demands of the heart by what mechanism?

The very first generation that beta-blockers were non-selective, definition that they clogged both beta-1 (β1) and also beta-2 (β2) adrenoceptors. Second generation beta-blockers are more cardioselective in the they are reasonably selective for β1 adrenoceptors. Note that this loved one selectivity can be lost at greater drug doses. Finally, the third generation beta-blockers room drugs that additionally possess vasodilator actions with blockade of vascular alpha-adrenoceptors.



Beta-blockers tie to beta-adrenoceptors situated in cardiac nodal tissue, the conducting system, and also contracting myocytes. The heart has both β1 and β2 adrenoceptors, back the predominant receptor form in number and role is β1. This receptors mainly bind norepinephrine the is released from forgiveness adrenergic nerves. Additionally, they tie norepinephrine and epinephrine the circulate in the blood. Beta-blockers stop the common ligand (norepinephrine or epinephrine) from binding to the beta-adrenoceptor by contending for the binding site.

Beta-adrenoceptors space coupled to a Gs-proteins, which activate adenylyl cyclase to form cAMP from ATP. Raised cAMP activates a cAMP-dependent protein kinase (PK-A) that phosphorylates L-type calcium channels, which reasons increased calcium entry into the cell. Boosted calcium entrance during action potentials leads to enhanced release the calcium through the sarcoplasmic delusion in the heart; this actions increase inotropy (contractility). Gs-protein activation also increases heart rate (chronotropy). PK-A additionally phosphorylates sites on the sarcoplasmic reticulum, which command to intensified release that calcium through the ryanodine receptor (ryanodine-sensitive, calcium-release channels) connected with the sarcoplasmic reticulum. This provides much more calcium because that binding the troponin-C, which improves inotropy. Finally, PK-A have the right to phosphorylate myosin irradiate chains, which may add to the optimistic inotropic result of beta-adrenoceptor stimulation.

Because there is typically some level of sympathetic tone on the heart, beta-blockers space able to mitigate sympathetic impacts that generally stimulate chronotropy (heart rate), inotropy (contractility), dromotropy (electrical conduction) and lusitropy (relaxation). Therefore, beta-blockers cause decreases in heart rate, contractility, conduction velocity, and also relaxation rate. These drugs have actually an even greater effect when over there is elevated sorry activity.


Blood vessels

Vascular smooth muscle has actually β2-adrenoceptors that are normally activated through norepinephrine exit by sorry adrenergic nerves or by circulating epinephrine. This receptors, choose those in the heart, are coupled to a Gs-protein, which stimulates the formation of cAMP. Although increased cAMP boosts cardiac myocyte convulsion (see above), in vascular smooth muscle an increase in cAMP leader to smooth muscle relaxation. The reason for this is that cAMP inhibits myosin irradiate chain kinase the is responsible because that phosphorylating smooth muscle myosin. Therefore, rises in intracellular cAMP resulted in by β2-agonists inhibits myosin light chain kinase thereby developing less contractile pressure (i.e., fostering relaxation).

Compared come their effects in the heart, beta-blockers have fairly little vascular effect due to the fact that β2-adrenoceptors have actually only a tiny modulatory duty on basal vascular tone. Nevertheless, blockade of β2-adrenoceptors is linked with a small degree the vasoconstriction in many vascular beds. This occurs because beta-blockers eliminate a little β2-adrenoceptor vasodilator affect that is typically opposing the an ext dominant alpha-adrenoceptor mediated vasoconstrictor influence.

Therapeutic Indications


Cardiac Effects

Decrease contractility(negative intropy)Decrease be safe rate(negative lusitropy)Decrease love rate(negative chronotropy)Decrease conduction velocity(negative dromotropy)

Vascular Effects

Smooth muscle contraction(mild vasoconstriction)

Beta-blockers are provided for treating hypertension, angina, myocardial infarction, arrhythmias and heart failure.


Beta-blockers diminish arterial blood press by reducing cardiac output. Numerous forms the hypertension are associated with an increase in blood volume and also cardiac output. Therefore, to reduce cardiac calculation by beta-blockade deserve to be an effective treatment for hypertension, particularly when used in conjunction v a diuretic. Acute treatment with a beta-blocker is not really effective in to reduce arterial pressure because of a compensatory boost in systemic vascular resistance. This might occur due to the fact that of baroreceptor reflexes functioning in conjunction with the removed of β2 vasodilatory impacts that usually offset, to a tiny degree, alpha-adrenergic mediated vascular tone. Chronic treatment with beta-blockers lowers arterial pressure an ext than acute treatment possibly because of lessened renin release and also effects the beta-blockade on central and peripheral nervous systems. Beta-blockers have an additional benefit together a therapy for hypertension in the they inhibit the release of renin by the kidneys (the release of i beg your pardon is partly regulated by β1-adrenoceptors in the kidney). To decrease circulating plasma renin leader to a diminish in angiotensin II and aldosterone, which boosts renal lose of sodium and also water and also further diminishes arterial pressure.

Hypertension in some patients is resulted in by emotional stress, i m sorry causes amplified sympathetic activity. Beta-blockers can be very effective in this patients.

Beta-blockers are offered in the preoperative monitoring of hypertension led to by a pheochromocytoma, which results in elevated turn catecholamines. When provided for this condition, the blood push is first controlled utilizing an alpha-blocker such together phenoxybenzamine, and then a beta-blocker deserve to be carefully administered to alleviate the excessive cardiac stimulation through the catecholamines. It is vital that a beta-blocker is administered only after sufficient blockade that vascular alpha-adrenoceptors so the a hypertensive crisis does not happen as a an outcome of unopposed alpha-adrenoceptor stimulation.

Angina and myocardial infarction

The antianginal results of beta-blockers space attributed to their cardiodepressant and hypotensive actions. By reducing love rate, contractility, and also arterial pressure, beta-blockers reduce the job-related of the heart and the oxygen demand of the heart. Reduce oxygen need improves the oxygen supply/demand ratio, which deserve to relieve a patience of anginal pain that is caused by a palliation in the oxygen supply/demand ratio as result of coronary artery disease. Furthermore, beta-blockers have been discovered to be really important in the treatment of myocardial infarction in that they have actually been displayed to decrease mortality. Their benefit is derived not only from enhancing the oxygen supply/demand ratio and also reducing arrhythmias, but likewise from their ability to inhibit subsequent cardiac remodeling.

See more: Why Did Supporters Of Manifest Destiny Argue That Us Expansionism Was Not Imperialism?


The antiarrhythmic nature beta-blockers (Class II antiarrhythmic) are related to their capacity to inhibit sympathetic influences on cardiac electrical activity. Forgiveness nerves rise sinoatrial node automaticity by raising the pacemaker currents, which rises sinus rate. Sympathetic activation also increases conduction velocity (particularly at the atrioventricular node), and stimulates aberrant pacemaker activity (ectopic foci). This sympathetic influences are mediated primarily through β1-adrenoceptors. Therefore, beta-blockers deserve to attenuate these sympathetic effects and thereby diminish sinus rate, decrease conduction velocity (which have the right to block reentry mechanisms), and also inhibit aberrant pacemaker activity. Beta-blockers also affect non-pacemaker action potentials through increasing action potential duration and the effective refractory period. This effect can beat a major role in blocking arrhythmias caused by reentry.